Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations
Identifieur interne : 000172 ( Main/Exploration ); précédent : 000171; suivant : 000173Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations
Auteurs : Anne Marthe Meppelink [Pays-Bas] ; Bauke M. De Jong [Pays-Bas] ; Laura K. Teune [Pays-Bas] ; Teus Van Laar [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
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Abstract
In our previous functional magnetic resonance imaging study, Parkinson's disease (PD) patients with visual hallucinations (VH) showed reduced activations in ventral/lateral visual association cortices preceding image recognition, compared with both PD patients without VH and healthy controls. The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.
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DOI: 10.1002/mds.23375
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The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Groningue (province)</li></region><settlement><li>Groningue (ville)</li></settlement><orgName><li>Université de Groningue</li></orgName></list><tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Meppelink, Anne Marthe" sort="Meppelink, Anne Marthe" uniqKey="Meppelink A" first="Anne Marthe" last="Meppelink">Anne Marthe Meppelink</name></region><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M." last="De Jong">Bauke M. De Jong</name><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M." last="De Jong">Bauke M. De Jong</name><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M." last="De Jong">Bauke M. De Jong</name><name sortKey="Meppelink, Anne Marthe" sort="Meppelink, Anne Marthe" uniqKey="Meppelink A" first="Anne Marthe" last="Meppelink">Anne Marthe Meppelink</name><name sortKey="Meppelink, Anne Marthe" sort="Meppelink, Anne Marthe" uniqKey="Meppelink A" first="Anne Marthe" last="Meppelink">Anne Marthe Meppelink</name><name sortKey="Teune, Laura K" sort="Teune, Laura K" uniqKey="Teune L" first="Laura K." last="Teune">Laura K. Teune</name><name sortKey="Teune, Laura K" sort="Teune, Laura K" uniqKey="Teune L" first="Laura K." last="Teune">Laura K. Teune</name><name sortKey="Teune, Laura K" sort="Teune, Laura K" uniqKey="Teune L" first="Laura K." last="Teune">Laura K. Teune</name><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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